The Nanotek microfluidic synthesis system is a modular, flow-based microchemistry system that can alternate between microscale and macroscale processes. The system allows the user maximum flexibility when producing radio-labeled imaging agents for research and clinical applications.

The heart of the system is a flow through microreactor that allows the user to optimize tracer synthesis and production for both research and clinical applications. Being flow through means that despite the small volume of the reactor itself the reaction volume is determined by the user not the dimensions of the reactor. For optimization purposes productivity can be enhanced dramatically whilst at the same time minimizing material consumption. For production purposes the microreactor has demonstrated considerable improvement in RCY and RCP compared to conventional vial based reactors and even labeled precursors previously unreactive to attempts to incorporate isotope.

22 Tracers have been optimized and produced using the Nanotek platform during the last two years and in house application notes have also been produced for:

• Altanserin
• Simultaneous production of C11 Raclopride and DTBZ for human and preclinical doses respectively.
• FLT

Scientific publications to date include:

A microfluidic flow chemistry platform for organic synthesis: the Hoffman rearrangement
Palmieri, A.; Ley, S.V.; Hammond, K.; Polyzos, A.; Baxendale, I.R.
Tetrahedron Letters, July 2009, 50 (26):3287-3289.

Synthesis of [18F]Fallypride in a Micro-Reactor: Rapid Optimization and Multiple-Production in Small Doses for Micro-PET Studies
Lu, S.; Giamis, A.M.; Pike, V.W.; Current Radiopharmaceuticals, July 2009, 2:49-55.

A Microfluidic Approach to the Preparation of Radiometal-based probes
Causey, P.W.; Simms, R.; Stephenson, K.; Valliant, J.F.; Journal of Nuclear Medicine Abstracts, June 2009.

Single-Stop High-Yield Radiosynthesis and Evaluation of a Sensitive F-Labeled for Imaging Brain Peripheral Benzodiazepine Receptors with PET
Briard, E.; Zoghbi, S.S.; Simeon, F.G.; Imaizumi, M.; Gourley, H.; Shetty, H.U.; Lu, S.; Fujita, M.; Innis, R.B.; Pike, V.W.; J. Med. Chem., January 02, 2009, 52(3).

Demonstration systems are available throughout North America for short term evaluation purposes to anyone seeking confirmation of the synthesis claims of the system or to compare microfluidic tracer production capability versus conventional approaches.

To receive more information regarding the Nanotek system, applications and / or request an onsite demonstration please contact Kelvin@flowtrek.com or call 607 351 7742