The drug discovery process involves the synthesis of many hundreds if not thousands of compounds and their subsequent screening for both desirable and equally if not more so, undesirable characteristics.
In today’s world of spiraling costs and the growing need to minimize raw material consumption, technologies are evolving that aim to address some if not most of these issues.
One goal of the Cresset FieldStere software is to support the medicinal chemist by helping to minimize the number of syntheses needed during the optimization phase of a drugs development.
In summary the software is able to assist Medicinal or Radio Chemists
- Efficiently Optimize active compounds
- Reduce time & costs by synthesizing fewer, but better compounds
- Increase the innovation by identifying a broader range of molecules
- Improve library designs
- Identify replacements for part of a molecule without affecting the underlying activity
- Generate ideas for new and improved molecules
- Find out solutions to biological problems such as ADME and toxicity
- Indentify compounds with better biological properties
- Discover novel IP (alternative compounds with the same activity not covered by the patent)
- Rapidly assess IP coverage around a given target
- Patent Bust
- Construct comprehensive patent claims to fully protect your inventions
If you would like to evaluate the software, request a webinar to understand more about FieldStere’s capabilities or to host an onsite presentation please contact Kelvin@flowtrek.com or call 607 351 7742
For more detailed information regarding Cresset products and to review references please click on www.cresset-bmd.com to be directed to the Cresset website.
An article, Overcoming the limitations of chemical structure, is also available at www.cresset-bmd.com/downloads/ddw09.pdf.
For brochures on FieldStere and other Cresset software products developed specifically for Medicinal chemistry please contact Kelvin@flowtrek.com or call 607 351 7742
Experience the advantage of field based chemistry!
Above left: Atorvastatin (lipitor), the world's top selling drug.
Above right: An unprotected, potentially biososteric compound discovered by FieldStere likely to have similar biological activity.
The Field based chemistry revolution
Changing the way we think and work with small molecules.
Above left: 2D structures of structurally diverse bioisoteres both active at PDE3, cAMP (the natural substrate) and SKF93741, a PDE3 inhibitor.
Above right: The Field patterns of the compounds receal that they are biologically identical and share the same activity.
